Text Size

Yoyo Dieting Leads to Drug Withdrawal-Like Stress Response

posted 11:14 PM EST, Mon November 09, 2009
-- filed under: | | |
Yoyo Dieting Leads to Drug Withdrawal-Like Stress Response © Photo Credit: Lee Carson

Researchers at the Scripps Institute say that not only does Yoyo dieting fail to induce lasting weight loss, it can actually trigger a drug withdrawal-like stress response in the brain that can lead to overeating and weight gain.

Researchers at the Pearson Center for Addiction and Alcoholism Research and the Scripps Research Institute say that yoyo dieting can cause changes in the brain that are likely to induce weight gain.

The researchers knew that positive reinforcement can help people continue with weight loss. For example, when you can suddenly fit into previously tight clothes you may gain the motivation to continue your weight loss efforts. They wanted to know whether negative reinforcement, for example - dieting makes you feel bad so you eat more to feel better again, may play a role in those that fail to lose weight.

The Test

In an animal model experiment, rats were given periodic access to sweet and or fatty foods and then healthy but less tasty foods – in alternating cycles of 5 days of healthy food followed by 2 days of fatty/sweet foods. The rats were allowed to eat as much as they wanted. 

The Results

  • These rats started to eat less of the healthy foods and on days when only healthy foods were available, these rats avoided all stressful situations
  • When the fatty/sweet foods were made available, the rats could once again face stressful situations, but they ate far more than they needed to

When the researchers looked at what was happening at the neural level, they found:

  • During healthy food days, the yoyo dieting rats had 5 times the normal amount of a stress peptide in the brain that regulates fear, anxiety and stress
  • During days when the rats were allowed to eat fatty/sweet foods, levels of this peptide returned to normal

During healthy food says, the rats were in a literal state of withdrawal, very similar to a drug addiction withdrawal.

Alternating between dieting and bingeing leads to elevated feelings of stress during periods of healthy eating, and since this stress is relieved by binge eating, people are very likely to eat to feel better, and thus fail to lose weight – or even gain weight.

Senior author Eric Zorilla sums up the withdrawal-like consequences of yoyo dieting by saying, "Our findings suggest that intermittently eating sweet food changes the brain's stress system so that you might feel stressed, even though nothing that terrible has happened. In other words, you might be self-medicating stress-like symptoms of abstinence with that piece of pie.

The full research findings can be read at the Proceedings of the National Academy of Sciences, Nov. 9, 2009.


Email It Send this page Print It Print friendly page Subscribe Subscribe to this topic category
Creative Commons License
Copyright Notice
We welcome republishing of our content on condition that you credit Choose Help and the respective authors. This article is licensed under a Creative Commons License.

Join Thousands of Readers

who receive our weekly recovery newsletter.

Helpful Information
Use Gut Bacteria to Fight Anxiety and Depression
Gut Bacteria Protect Your Mental Health. Learn How to Protect Your Microbiome © NIAID
Imbalanced gut bacteria may increase your risk of anxiety, depression, obesity and a host of other diseases. Learn how digestive bacteria can cause anxiety and find out how dietary changes can help you instill or protect an optimal balance of beneficial bacteria. Read Article
Co-Occurring Disorders May 26, 2016
Childhood Obesity - Encourage Weight Loss
Childhood Obesity - How Parents Can Safely Encourage Weight Loss © Max Roeleveld
Obese kids should be encouraged to lose weight for greater physical and often mental health. Learn how to encourage weight loss, without increasing the risk of an eating disorder. Read Article
Eating Disorders March 06, 2008 (2)
How to Support a Teenager with an Eating Disorder
9 Important Rules for Supporting a Teenager with an Eating Disorder © pixieclipx
Learn how to effectively support a teen who is already receiving professional care, but who still needs a ton of support from the rest of the family. Read Article
Eating Disorders February 03, 2015
Like Our Site? Follow Us!

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.