Text Size
Smaller
Bigger

The Antipsychotic Medication Aripiprazole May Help Alcoholics Stop Drinking

posted 08:53 AM EST, Sat April 19, 2008
The Antipsychotic Medication Aripiprazole May Help Alcoholics Stop Drinking © Photo: Bistro Savage

The medication increases the sedative effects of alcohol while reducing the pleasurable, or euphoric effects.

A drug more typically given to treat psychosis may help alcoholics break their addiction.

Dr. Henry R. Kranzler, from the University of Connecticut, knew that the atypical antipsychotic, Aripiprazole, worked on some of the same neural systems as are affected by alcohol, and he choose to investigate formally what impact the use of the medication in otherwise healthy individuals had on alcohol consumption.

18 healthy study participants, with an average age of 26 and a history of moderate drinking in the previous 90 days, were given alcohol in a laboratory. Some were also given only a placebo, some were also given a 2.5 mg dosage of Aripiprazole and some were also given a 10 mg dosage.

Each participant was given three alcoholic drinks, the exact quantities modified to equalize for the effects of age, weight and gender, and their reactions were noted, both physiologically, and subjectively.

Physiologically, Aripiprazole increased heart rate, and larger doses increased it more. Subjectively, participants reported that the medication made them feel more tired and less euphoric after consuming alcohol, and the greater the dosage, the larger the effect.

The medication was well tolerated by the subjects, with only some minor side effects reported.

Kranzler concludes that the medication could help alcoholics reduce their drinking. The medication takes away much of the pleasure of alcohol, increases the sedative effects of drink, making it less likely to drink to excess, and is generally a well tolerated drug.

Email It Send this page Print It Print friendly page Subscribe Subscribe to this topic category
Creative Commons License
Copyright Notice
We welcome republishing of our content on condition that you credit Choose Help and the respective authors. This article is licensed under a Creative Commons License.

Join Thousands of Readers

who receive our weekly recovery newsletter.

Helpful Information
Understanding How the Alcoholic Thinks
Understanding the Insanity of Alcoholism: How the Alcoholic Thinks © Flood
One of the finest compliments I receive from recovering alcoholics is that despite the fact that I am not an alcoholic, I understand how their minds work. I have profound respect for all the old sayings in AA. Some are open to interpretation - the "insanity of our disease" is a literal statement. Read Article
Alcoholism September 21, 2012 (227)
Alcohol Addiction – the Straight Facts
Alcohol Addiction (Alcoholism) – Learn the Facts © Josep Salvia I Bote
The difference between alcohol abuse and alcohol addiction (alcoholism), what puts you at risk of becoming an alcoholic and what to do once you’ve crossed that invisible line to addiction. Read Article
Addictions February 22, 2013
How to End an Addiction-Damaged Relationship
Guidelines for Ending an Addiction-Destroyed Relationship © Merlijen Hoek
What do you do when the person you love gets consumed by a disease (addiction) that's beyond your control? How do we know when it's time to leave and how do you manage to adjust to life without your actively addicted partner? Read Article
Living With An Addict November 03, 2013 (7)
Like Our Site? Follow Us!

This website is certified by Health On the Net Foundation. Click to verify. This site complies with the HONcode standard for trustworthy health information:
verify here.