DeSoto County Drug Rehabs & Treatment

Outpatient Rehab

Oxford Outpatient Treatment Center is located at 1150 Church Road West in Southaven, Mississippi, under the Oxford Treatment Center brand of American Addiction Centers. According to SAMHSA's 2026 survey, it provides outpatient and intensive outpatient substance use treatment for adults, with private insurance and self-pay accepted.

Outpatient Rehab

Region IV Mental Health Services is a community mental health center that has served north Mississippi since 1972 and opened in DeSoto County in 2010; this is its Hernando office on Highway 51. It provides outpatient and intensive outpatient substance use treatment, medication-assisted treatment using FDA-approved medications alongside counseling, and DUI programs, with telehealth available. Region IV states that no one is excluded from services because of inability to pay or because of who pays — including Medicare, Medicaid or CHIP — and it offers sliding-fee discounts. Medicaid, Medicare, private and military insurance, state funding and self-pay are all accepted.