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Although the name would imply otherwise, atypical depression may in fact be the most commonly experienced form of depression.

A subtype of major depression (clinical depression) sufferers of atypical depression tend to experience depressive symptoms with less severity and experience a typically earlier age of onset, but the biggest difference between major and atypical depression is mood reactivity.

People with atypical depression can experience positive emotions in response to positive life events (mood reactivity). Someone with atypical depression might experience joy and happiness while out with friends or family, and return to despair once again home alone; while someone with major depression could not experience an elevated mood in that same situation.

The Symptoms of Atypical Depression

People with atypical depression meet the diagnostic criteria for major depression, with a couple of important distinctions.

  • They experience mood reactivity, which is the ability to feel pleasure in response to positive life events.
  • They experience at least 2 of the following additional symptoms:
    • Heaviness in the limbs
    • Overeating, craving carbohydrates particularly
    • Oversleeping
    • A fear and sensitivity to social rejection

Atypical depression often has an earlier age of first onset, frequently during the teenage years.

People with atypical depression can experience and display positive emotions in enjoyable situations. This characteristic symptom of atypical depression serves to very well camouflage the disorder to friends and family that might otherwise express concern; and so atypical depression is a vastly under diagnosed condition. The duration of symptoms can range from a disorder that disappears after months, to one that lingers for decades

People with atypical depression symptoms are advised to seek treatment with a psychiatrist familiar with the disorder, as this subtype of depression requires appropriate diagnosis and sometimes differing treatments.

What Causes Atypical Depression?

Atypical depression remains an incompletely understood disorder of the brain. Scientists suspect that altered neural chemistry plays a significant role in the disorder, with the neurotransmitters dopamine, serotonin and norepinephrine most frequently implicated.

While the exact causes of atypical depression remain unknown, researchers can say that certain life and genetic factors increase the risks.

Risk factors include:

  • A genetic history of depression (the closer the family member the greater the risk)
  • Serious chronic illness
  • Substance abuse
  • Social isolation
  • Sexual, physical and emotional abuse
  • Chronic feelings of guilt
  • Strong grief
  • Major life changes


Atypical depression responds well to 2 types of treatment:

  • Psychotherapy and or cognitive behavioral therapy
  • Medication

Atypical depression patients will typically participate in both forms of treatment, to maximize the odds that at least one type will provide effective symptoms relief.

The medications that work for atypical depression differ slightly from the medications often prescribed for major depression, and it is for this reason that a correct diagnosis is critical.

Tricyclic antidepressants do not work for people with atypical depression. MAOIs, a different subtype of medication, do work very well, but doctors are sometimes reluctant to prescribe them due to side effects and certain dietary restrictions associated with their use. SSRIs such as Prozac or Zoloft may provide symptoms relief, but insufficient research exists to document their efficacy. Because patients tolerate SSRIs better than MAOIs, doctors will often try SSRIs first.


MAOIs may work well, but they can be tricky to live with. People on MAOIs must avoid certain foods that contain tyramine, such as cheeses, fermented foods and many others. Eating foods high in tyramine while on MAOIs can cause a dangerously high level of tyramine in the body, which can lead to symptoms such as confusion, heart problems, nausea and others.

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Page last updated Apr 28, 2011

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