One of the hallmarks of withdrawal to many substances, most notably opiates like heroin or pain medications, is the experience of extreme discomfort and pain during the initial days of withdrawal. Unfortunately, many of the more potent medications available for pain work as opiates, and cannot be used in an opiate drug cessation program. Pain medications used in drug dependence treatments are medications that induce pain relief outside of the brain, and some commonly used medications are acetaminophen, aspirin, and most commonly, ibuprofen.

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